A "serious crash" closed part of Lititz Pike between Waverly Avenue and Petersburg Road Wednesday afternoon for about an hour.
Manheim Township police said the road was reopened at 12:34 p.m.
Two vehicles collided head-on just before 11:30 a.m., police said.
It is currently unknown how many people were involved or if there were any injuries.
According to 511pa.com, traffic was backed up from Bluebell Drive to Meadow Lane.