Route 222 North has reopened after a three-car accident closed the road Tuesday afternoon, according to dispatch reports.
Three people were sent to the hospital after the accident in Brecknock Township, according to state police Trooper James Spencer.
Two individuals were transferred to Lancaster General. The third was transported to Reading Hospital, Spencer said.
Both lanes were closed at the turnpike interchange/Denver exit for about 30 minutes.
Information related to the severity of the injuries was not immediately available.