Two people were taken to a hospital following a three-vehicle crash on Route 441 (River Road) in East Donegal Township.

A flatbed tow truck rear-ended a sport utility vehicle while both were heading north around 9 a.m., causing the SUV to veer into the south-bound lane, where it struck a pickup truck head-on, according to Sgt. Scott Drexel of Mount Joy Borough Police Department.

First responders removed the driver's side back door from the SUV remove the driver. The drivers of the SUV and the tow truck were taken to a  hospital, but their conditions were not known. The pickup driver did not have any major injuries. The drivers' names were not immediately available. There were no passengers in any of the vehicles.

River Road was reopened shortly after 12:30 p.m., according to county dispatch.

It's one of four crashes in Lancaster County Thursday morning, at least two of which closed down portions of roads, including a tractor-trailer crash that affected traffic on the Pennsylvania Turnpike in Denver.

This story will be updated.

Here's what we know about the earlier crashes:

A crash involving a tractor-trailer stopped traffic this morning on the turnpike. 

According to 511PA.com and Lancaster County-wide Communications, a portion of the turnpike was shut down following a tractor-trailer crash that left one person trapped. 

The crash occurred around 7 a.m. and was between the Lebanon-Lancaster and Reading exit, near mile marker 284.7. 

Only the left lane of traffic was affected by the crash, but both lanes came to a stop in order to removed the tractor-trailer from the scene.

Crews also responded to a crash in East Hempfield Township, near Rohrerstown Road and Spring Valley Road, for a report of a Class 2 vehicle accident. 

It closed a portion of Spring Valley Road. Crews towed the car and cleaned up by about 8:50 a.m.